President Biden is expected to name Jeffrey D. Zients, his former coronavirus response coordinator, as the next White House chief of staff, replacing Ron Klain, who has run Mr. Biden’s White House since the president took office two years ago. Klain has announced that he will step down sometime after the State of the Union address on Feb. 7.

An entrepreneur and management consultant, who organized the largest vaccination campaign in American history, Mr. Zients is widely respected in Biden circles as a strong and capable leader. He has been entrusted with some of the trickiest management tasks of the past two Democratic administrations — to fix the botched website of Mr. Obama’s new healthcare program, and to run Mr. Biden’s Covid-19 pandemic through successive variant waves.

Over the past two decades, he made Fortune magazine’s list of the 40 richest Americans under 40 (just two slots below a young Elon Musk). He reported assets between $76 million and $419 million on 2022 financial forms.

The president is likely to continue keeping Mr. Klain close, according to an unnamed source, The New York Times reported.